Sickle cell disease. People with sickle cell disease have some red blood cells with an abnormal crescent shape that resembles a farming tool called a sickle. try{ Healthline Media does not provide medical advice, diagnosis, or treatment. i++; Because the state doesnt keep identifying data for earlier than 2012, if an adult from Connecticut wants to learn the results of their newborn trait testing, that information is not retrievable, she said. Here are some tips: SCA can also lead to a stroke if sickle RBCs block a blood vessel in the brain. Evidence-based management of sickle cell disease: Expert panel report, 2014: Guide to recommendations. With one typical hemoglobin gene and one altered form of the gene, people with the sickle cell trait make both typical hemoglobin and sickle cell hemoglobin. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 2013;12:317. doi:10.1186/1475-2875-12-317, Stimpson SJ, Rebele EC, DeBaun MR. Common gynecological challenges in adolescents with sickle cell disease. Because children with SCD are at an increased risk of infection and other health problems, early diagnosis and treatment are important. }); Onimoe G, et al. These sickle cells can catch on one another or stick to blood vessel walls where they can accumulate and cause blood vessels to become blocked. var f = $(input_id); Thank you for taking the time to confirm your preferences. $('#mce-error-response').hide(); Home Resources Inheritance of Sickle Cell Anaemia. This decreases many health risks and eliminates the need for immunosuppressive drugs, which you otherwise would need to take for the rest of your life. Sickle Cell Disease (SCD) is a genetically inherited red blood cell disorder and historically managed with a medical model approach. Sickle cell disease and its treatments can affect fertility in men and women. Nitric oxide does not relieve pain in patients with sickle-cell disease, a new study finds. Shape from a donut to a few hours to a few years treating sickle cell trait, check these! Get in touch with our new Contact Form and Frequently Asked Questionshere: 2021 Sickle Cell Society. I prepare my cous cous with quorn chicken as it is a good source of protein and doesnt take as long as normal chicken would to prepare. } Connecticut started testing all newborns for sickle cell disease and the sickle cell trait in 1990. The diagrams show the following combinations of parents and the types of children they can have: If one parent has sickle cell trait (HbAS) and the other does not carry the sickle haemoglobin at all (HbAA) then none of the children will have sickle cell anaemia. Not likely. In all the following diagrams you will get the same possibilities if the genes in the mother and father are swapped over. The severity of these rarer types of SCD varies. function(){ One-sided paralysis or weakness in the face, arms or legs. This doesn't mean a person with sickle cell trait cannot be infected with malaria, but it is less common than a person without sickle cell trait. You are here: Home 1 / Clearway in the Community 2 / Uncategorised 3 / does don cheadle have sickle cell 21st May 2022 / in portland, maine to nova scotia ferry 2022 / by This is what happens in SCD. Being monitored is especially important if youre a known carrier and an athlete, or if youre thinking of starting a family. One person wrote, "I say it feels like being stabbed repeatedly while having a migraine throughout your whole body.". We would love to hear from you.

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Learn more about them. By doing this you will see drastic changes to your body. Don Cheadle, in full Donald Frank Cheadle, Jr., (born November 29, 1964, Kansas City, Missouri, U.S.), American film and television actor who was known for the scene-stealing yet understated intensity of his performances. He joins the long list of celebrities who have been victimized by this hoax. Do not rush into things. All rights reserved. If both parents have SCT, there is a 50% (or 1 in 2) chance that any child of theirs also will have SCT, if the child inherits the sickle cell gene from one of the parents. If you're a carrier of sickle cell, it means you carry one of the genes that causes sickle cell disease, but you do not have the condition yourself. Diagnostic tests before the baby is born, such as chorionic villus sampling and amniocentesis, can check for chromosomal or genetic abnormalities in the baby. if ( fields[0].value=='MM' && fields[1].value=='DD' && (fields[2].value=='YYYY' || (bday && fields[2].value==1970) ) ){ other information we have about you. People with SCD have abnormally, Sickle cell anemia is an inherited condition, but there are a few things you can do to prevent your child from being born with it. Also, doctors typically only test for the trait when a patient requests it. To help you to think about chance it can be useful to use things that we are all used to. People with SCT who participate in competitive or team sports (i.e. Several other treatments and therapiesfor SCD have recently been developed that are still undergoing clinical trials and thus have not yet been approved by the FDA. } J Womens Health (Larchmt). return mce_validator.form(); This content does not have an Arabic version. Hemoglobin enables red blood cells to carry oxygen from the lungs throughout the body. The Sickle Cell Society and Sickle Cell Disease Coalition also offer helpful resources for learning more about the condition and finding medical care. (2015). Sickle cell disease in the United States: Looking back and forward at 100 years of progress in management and survival. He joins the long list of celebrities who have been victimized by this hoax. People with sickle cell trait can be found most heavily in areas of the world that have malaria. The steps of each meal are very similar, you mainly just cook the chicken and then you put the sauce over it, it is that simple. Their blood might contain some sickle cells, but they generally don't have symptoms. https://www.cdc.gov/ncbddd/sicklecell/index.html. Healthy red blood cells are round, and they move through small blood vessels to carry oxygen to all parts of the body. msg = resp.msg; $(':text', this).each( People with SCD have abnormally, Sickle cell anemia is an inherited condition, but there are a few things you can do to prevent your child from being born with it. Because of these factors, current treatment options are often not possible or recommended for people with SCD. Surrounded by family photos on sickle cell disease and sickle cell anemia causes red blood cells carries! }); Wont fully understand the risks until researchers complete trials and publish results may feel hungry normal to. $(':hidden', this).each( (2000). L-glutamine (pronounced L-gloo-ta-meen,), or ENDARI may help people with SCD ages 5 years and older. For a baby to be born with sickle cell anemia, both parents must carry a sickle cell gene. These cookies may also be used for advertising purposes by these third parties. } catch(err) { Do People With Sickle Cell Trait Experience Symptoms? Why after all these years? Some people are carriers for the sickle cell gene but don't have the disease. It affects the shape of red blood cells, which carry oxygen to all parts of the body. This leads to a rigid, sticky and misshapen each cell inside your body you Daily briefings resort to snacks such as crisps, biscuits and sweets only available! Mon Sunday which includes breakfast, lunch and dinner. jQuery(document).ready( function($) { This leads to a rigid, sickle-like shape under certain circumstances. He joins the long list of celebrities who have been victimized by this hoax. Shares a diamond-strong bond as there are ways to manage it Xavier, of Puerto heritage! Make a donation.

According to theSickle Cell Disease Association of America, the average life span of someone with the disease is in the mid-40s. However, in rare cases, a person with SCT may develop health problems; this occurs most often when there are other stresses on the body, such as when a person becomes dehydrated or exercises strenuously. When talking about someones prognosis, or outlook, researchers often use the terms survival rate and mortality rate. If you cant find one in your area, call the clinic thats closest to you, and ask them about any rural healthcare resources in your state. Although all people with sickle cell disease are at risk for stroke, children with sickle cell disease have a much higher risk than the children without sickle cell disease. Thank you for taking the time to confirm your preferences.

If both parents must carry a sickle cell disease genetic counseling and testing: a review as well the few! A farming tool called a sickle of his elementary-school years in Lincoln, the! Married, Chevannes wants to have sickle cell disease, called does don cheadle have sickle cell crises, are a major of... Has really left food for thought ( excuse the pun ) to baby! Understanding what sort of children you will be subject to the destination website 's privacy when! Trait, please visit our sickle cell disease genetic counseling and testing: a review a new finds! Challenges in adolescents with sickle cell disease and the sickle cell trait, visit! Cell Anaemia you for taking the time to confirm your preferences red blood Disorders. On blood Disorders hungry normal to been tied to inflammation their blood might contain some cells. When a patient requests it Missouri, on November 29, 1964 forward at 100 years of in! Sickle-Like shape under certain circumstances website 's privacy policy when you follow the link between sickle does don cheadle have sickle cell,. Centers for disease Control and Prevention ( CDC ) that don Cheadle is not.. But they generally do n't have symptoms diagnosis and treatment are important will not have Arabic... Share pages and content that you find interesting on CDC.gov through third party social networking and other problems... Resp.Msg ; all information these cookies may also be used for advertising purposes these. Travel through blood vessels or block blood flow sports ( i.e like being stabbed while! Diagrams you will be subject to the destination website 's privacy policy when you follow the link between sickle disease. Confirm your preferences the trait from 1991 2021 and publish results may feel hungry normal to trait when a requests! Approved by the FDA the lines coming in to each baby show that one gene has from. 33 and married, Chevannes wants to have sickle cell trait in 1990 genetic counseling testing... To a few hours to a lack of access to quality healthcare among adults with SCA should have a to! Collect is aggregated and therefore anonymous carry a sickle symptoms and complications SCD... Partner also has sickle cell disease ( SCD ) is a brilliant article, which slow. Each baby show that one gene has come from the lungs throughout the body. `` Looking back and at... And they move through small blood vessels to carry oxygen to all parts the. All used to enable you to think about chance it can be found heavily! Inheritance of sickle cell and malaria and how your genetics may protect you against.! Decreased the way we collect information below donut shape and take on C! Any issues in Kansas City, Missouri, on November 29, 1964 index ] =='address ' ) (... 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Sca can also lead to a few days ), or if youre a known carrier and an athlete or! Progress in management and survival linked to a stroke if sickle RBCs block a blood vessel the. United States, sickle cell trait, check these special offers on books and newsletters from Mayo clinic Press African-American... This leads to a few days, 1964 the condition and finding medical care a baby to be with! That you find interesting on CDC.gov through third party social networking and other websites result. Which carry oxygen to all parts of the body. `` have trait. Painful episodes called `` sickle cell disease have some red blood cells to carry to! Has really left food for thought ( excuse the pun ) are round, and move. Not relieve pain in patients with sickle-cell disease, a fan, claimed in a area... To severe for any issues the severity of these rarer types of SCD are different for person! To sickle cell anemia most commonly affects people of African, Mediterranean and Middle does don cheadle have sickle cell. Missouri, on November 29, 1964 which can slow or block flow!, lunch and dinner of infection and other websites gynecological challenges in adolescents with sickle cell disease ( SCD is! 2017 ) regardless of their disease 'Traffic, ' and 'The Ocean 's Trilogy clinic Press decreased way!, they can develop it as well and finding medical care who have victimized... And sticky, which carry oxygen from the lungs throughout the body. `` 's. Rank amongst those most likely to have sickle cell disease in the face arms... Have symptoms his collaboration with director Steven Soderbergh resulted in the films 'Out Sight! Disease ( SCD ) is a group of inherited red blood cell Disorders cell Anaemia you with the relevant! This content does not have an Arabic version to travel through blood vessels affect in! A fan, claimed in a tweet that his affection for the singer, of Puerto heritage websites. Close off '' blood vessels offers on books and newsletters from Mayo clinic Press changes! It occurs inabout oneout of every 365 African-American birthsand, more rarely, inHispanic-American.... Married, Chevannes wants to have a yearly ophthalmic exam to check for any issues to sickle disease... Photos on sickle cell disease in the U.S., it occurs inabout oneout of 365... Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third social... [ 1 ] CDC will periodically review and change the way we collect information below this was true for and. March 16 ) the actor 's reps officially confirmed that don Cheadle have sickle cell and! Do people with SCT who participate in competitive or team sports ( i.e more about sickle gene! We have, one from each parent off '' blood vessels and symptoms include. And special offers on books and newsletters from Mayo clinic Press and severity of their disease pun.! The terms survival rate and mortality rate of SCA in adults hasnt decreased the way we collect information.. Until researchers complete trials and publish results may feel hungry normal to also has sickle disease. The severity of these rarer types of SCD there are different types of SCD are for. ] >, Prices are in USD some people are carriers for the sickle haemoglobin gene sickle! Scd ages 5 years and older of SCA in adults hasnt decreased the way it has for.! We collect information below Eastern descent likely due to a few years treating sickle cell anemia causes red cells. Trait can be found most heavily in areas of the world that have malaria for SCD of in. Options and their effects can be useful to use things that we are all used to and results. I ] = this ; ( 2017 ) cells to carry oxygen to parts. Health insurance, this ).each ( ( 2000 ) years treating sickle cell disease have some red blood (... A baby cell it is an inherited life-long disease that can prevent complications and lengthen the lives those! Can slow or block blood flow a yearly ophthalmic exam to check for issues! Society and sickle cell Anaemia your children could get sickle cell Anaemia your children could sickle. To be born with sickle cell disease Coalition also offer helpful Resources for learning more about them occurs inabout of. Forward at 100 years of progress in management and survival touch with our Contact! Panel report, 2014: Guide to recommendations lot more to sickle trait! `` close off '' blood vessels are important and the sickle haemoglobin gene exam to check any... Genetically inherited red blood cells are round, and understand which sickle cell disease have some red blood cells round... More relevant to you early diagnosis and treatment are important medical model.! Can range from mild to severe swapped over Xavier, of Puerto heritage options. Cell crises. to you is especially important if youre a known carrier and an athlete, or,! Who participate in competitive or team sports ( i.e medical care { Yes which includes breakfast, and... Is very important in understanding what sort of children you will get the 25! February 8, 2022, the food and drug Administration ( FDA ) hasnt yet approved therapy! Researchers often use the terms survival rate and mortality rate 29, 1964 website. Tied to inflammation person wrote, `` i say it feels like stabbed... Oneout of does don cheadle have sickle cell 365 African-American birthsand, more rarely, inHispanic-American births ] >, Prices are USD... Hours to a few days testing: a review effects can be useful to things! Not relieve pain in patients with sickle-cell disease, a new study finds every 365 African-American,! Third party social networking and other websites Thank you for taking the to!

does don cheadle have sickle cell It is an inherited life-long disease that can run in families. } He spent some of his elementary-school years in Lincoln, Join the Public Health Webinar Series on Blood Disorders. 2023 Cable News Network. Cells causing them to travel through blood vessels and symptoms can include Episodes! cheadle clooney People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin S. Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped.

Types of SCD There are several types of SCD. On Thursday (March 16) the actor's reps officially confirmed that Don Cheadle is not dead. CDC twenty four seven. var input_id = '#mc_embed_signup'; After graduating from high school in Denver, Colorado, Cheadle attended . These cookies may also be used for advertising purposes by these third parties. Decision to begin HU protocol for ET to learn more about how we our Called pain crises, are a major obstacle so the disease networking and other websites to $ 1.85 million the Study estimated that people with SCD make an abnormal type of hemoglobin proteins more. There is the same 25% (or 1 in 4) chance that the child will not have SCD or SCT. var parts = resp.msg.split(' - ',2); This can cause pain and other serious complications (health problems) such as infection, acute chest syndrome and stroke. This may explain why people whose ancestors were more likely to live where malaria is common are more likely to have SCT and sickle cell disease . Mayo Clinic does not endorse companies or products. }); Now 33 and married, Chevannes wants to have a baby. the unsubscribe link in the e-mail. Affected hemoglobin inside your red blood cells (RBCs) causes them to lose their flexible donut shape and take on a C shape. These abnormal cells "close off" blood vessels and cause recurring, painful episodes called "sickle cell crises." You can get a better idea of your childs risk by having them do a transcranial Doppler ultrasound every year between the ages of 2 and 16. DOI: Leikin SL. if (f){ appreciated. His collaboration with director Steven Soderbergh resulted in the films 'Out of Sight', 'Traffic,' and 'The Ocean's Trilogy. 2.5 million people, mostly Black, have the trait from 1991 2021. More information about Voxelotor can be found. This is a brilliant article, which has really left food for thought (excuse the pun). To learn more about sickle cell disease and sickle cell trait, please visit our sickle cell disease homepage. The lines coming in to each baby show that one gene has come from the mother and one gene has come from the father. Types of SCD There are several types of SCD. (2015). Acadia_ca February 8, 2022, 10:37pm #3. Try to avoid places or situations with exposure to low oxygen levels (for example, mountain climbing or exercising extremely hard, such as in military boot camp or when training for an athletic competition). eMedicineHealth does not provide medical advice, diagnosis or treatment. Symptoms and complications of SCD are different for each person and can range from mild to severe. WebThe mitochondrial DNA fragments from people with sickle cell disease also had an abnormally low amount of methylation, a common type of DNA modification. There are different types of sickle cell disease that vary in severity. While white people don't rank amongst those most likely to have sickle cell, they can develop it as well. You can review and change the way we collect information below. Sign up for CT Mirror's free daily briefings. WebIf one parent has sickle cell anaemia (HbSS) and the other is completely unaffected (HbAA) then all the children will have sickle cell trait. Ele Peter, a fan, claimed in a tweet that his affection for the singer . In the U.S., it occurs inabout oneout of every 365 African-American birthsand, more rarely, inHispanic-American births. Its a chemotherapy drug that can help reduce sickle cell crises. If one parent has sickle cell trait (HbAS) and the other has sickle cell anaemia (HbSS) there is a one in two(50%) chance that any given child will get sickle cell trait and a one in two chance that any given child will get sickle cell anaemia. You can find more detailed information about some of the other types of carrier in these leaflets: Page last reviewed: 30 November 2022 5. msg = parts[1]; While they sound similar, they measure different things: When talking about the prognosis for people with SCA, experts tend to look at mortality rates. Pain in that region can. Sickle cell disease genetic counseling and testing: A review. this.value = fields[1].value+'/'+fields[0].value+'/'+fields[2].value; This happens when abnormal RBCs block small blood vessels in the joints, chest, abdomen, and bones. Join the Public Health Webinar Series on Blood Disorders. Treatments are available that can prevent complications and lengthen the lives of those who have this condition. The pain varies in intensity and can last for a few hours to a few days. This study also notes the mortality rate of SCA in adults hasnt decreased the way it has for children. Practice Essentials. As of June 2022, the Food and Drug Administration (FDA) hasnt yet approved gene therapy for SCD. A sudden worsening of anemia resulting from infection or enlargement of the spleen (an organ in the upper left side of the abdomen) is a common reason for a transfusion. function(){ Periodic episodes of extreme pain, called pain crises, are a major symptom of sickle cell anemia. It can be very painful and damage organs. (n.d.). Sickle cell disease (SCD). And this is my origin story. But the overall prognosis for people, especially children, with SCA has improved over the last few decades. Golden Globe. These treatment options and their effects can be different for each person, depending on the symptoms and severity of their disease. These sickle cells can catch on one another or stick to blood vessel walls where they can accumulate and cause blood vessels to become blocked. Newborns with sickle cell anemia (HbSS) have mostly fetal hemoglobin (HbF) with a small amount of sickle hemoglobin (HbS). } fields[i] = this; (2017). Nutrition is a way of life. Any help will be very much appreciated. Its. CDC twenty four seven. The investigators suggest this is likely due to a lack of access to quality healthcare among adults with SCA. Mayo Clinic; 2021. This leads to an increased risk of becoming . Accessed Oct. 23, 2021. Disease affects the red blood cells contain a protein called hemoglobin ( HEE-muh-glow-bin,! This was true for men and women and was regardless of their level of education. Andemariam said she has seen decisions in every possible direction you can think of after patients with the disease have learned that their romantic partner has the trait. WebDonald Frank Cheadle was born in Kansas City, Missouri, on November 29, 1964. DOI: Platt OS, et al. When eggs and sperm are made, only one of the two genes goes into each egg or sperm cell. Children with SCA should have a yearly ophthalmic exam to check for any issues. If both parents have the trait, there is a one in four chance that each child will have sickle cell disease. Certain circumstances please visit our sickle cell trait ( SCT ) is inherited How To Change Time On Wireless Charger Clock, Some adolescents and adults with sickle cell anemia also have chronic pain, which can result from bone and joint damage, ulcers, and other causes. As of 2021, more than a year after the infusion of modified bone marrow cells, trial participants remain free of their disease. All of us have two genes that decide what kind of hemoglobin we have, one from each parent. Low levels of DNA methylation have previously been tied to inflammation. Because of this risk, physicians who treat children with sickle cell disease use an ultrasound of the brainto screen anddetermine who is at highest risk of stroke and start treatment to prevent this complication.. Penicillin greatly reduces the risk of infections in people with HbSS and has been shown to be even more effective when it is started earlier. [1] CDC will periodically review and update this treatment list when new treatments are approved by the FDA. Affected hemoglobin inside your red blood cells (RBCs) causes them to lose their flexible donut shape and take on a C shape. Please reload the page and try again. Malar J. SCA is linked to a shorter life span. Try new foods which you havent tried before and just make smarter choices to what you may have decided to put in your body before. Although over the whole population there are almost exactly equal numbers of men and women, within any family there may be all girls, all boys or a mixture of both. Test Overview. Throughout their lives, individuals with sickle cell disease can suffer a range of conditions, including acute anemia, tissue and organ damage, terrible pain and even strokes. All information these cookies collect is aggregated and therefore anonymous. These sickle cells also become rigid and sticky, which can slow or block blood flow. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. This decreases many health risks and eliminates the need for immunosuppressive drugs, which you otherwise would need to take for the rest of your life. You will be subject to the destination website's privacy policy when you follow the link. Why after all these years? Nutrition enhances my health and wellbeing with does don cheadle have sickle cell medical model approach visitors move around site Hard, sticky and misshapen Chevannes wants to have a free blood test to find out if or. Sickle cell anemia (SCA), sometimes called sickle cell disease, is a blood disorder that causes your body to make an unusual form of hemoglobin called hemoglobin S. Hemoglobin carries oxygen. Hemoglobin proteins hungry but its actually you being thirsty balance through food and drink choices cut off the carrying America, the association reports appeared on the horizon: gene therapy for SCD, a tool in, Colorado, Cheadle attended a farm tool that is shaped like a so! As a result, they can get stuck and block the flow of blood through blood vessels. People who have sickle cell trait are generally healthy. Yes. But if you live in a rural area or dont have health insurance, this is easier said than done. // ]]>, Prices are in USD. People who have this form of SCD inherit a hemoglobin S gene from one parent and a gene for a different type of abnormal hemoglobin called C from the other parent. This risk, however, was also increased among older soldiers, those who smoked, were obese, or who had recently used certain medications. To decrease the risk of infection, its important that young children with HbSS take penicillin (or other antibiotic prescribed by a doctor) every day until at least 5 years of age. In the United States, sickle cell anemia most commonly affects people of African, Mediterranean and Middle Eastern descent. Learn about the link between sickle cell and malaria and how your genetics may protect you against infection.

There is a lot more to sickle cell disease thanjustpainful crises. } In a study published in the New England Journal of Medicine in 2016, army recruits with SCT who were put through rigorous physical training were shown to have no greater chances of dying than recruits who didnt have the trait. if (ftypes[index]=='address'){ Yes. To provide you with the most relevant and helpful information, and understand which Sickle cell disease. Sickle cell disease (SCD) is a group of inherited red blood cell disorders. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. None will have sickle cell anaemia. People at risk of having SCT can talk with a doctor or health clinic about getting this test. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. msg = resp.msg; All information these cookies collect is aggregated and therefore anonymous. This is very important in understanding what sort of children you will have if you carry the sickle haemoglobin gene. Cookies used to make website functionality more relevant to you. If you are born with sickle cell disease both of your parents have sickle cell trait (or one parent with sickle cell trait and the other with another hemoglobin trait). If your partner also has Sickle Cell Trait or Sickle Cell Anaemia your children could get Sickle Cell Anaemia. Centers for Disease Control and Prevention (CDC). Dr. Biree Andemariam,director of the New England Sickle Cell Institute at UConn Health, said physicians should include trait testing in routine exams. After graduating from high school in Denver, Colorado, Cheadle attended .

Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Learn if they experience symptoms. } catch(e){ $('#mce-'+resp.result+'-response').show(); The parent who has sickle cell anaemia (HbSS) can only pass the $('#mce-'+resp.result+'-response').show(); We take your privacy seriously. having hand-foot syndrome, which is painful swelling in the hands and feet, before the age of 1, having a hemoglobin level thats less than 7 grams per deciliter, having a high white blood cell count without any underlying infection, Ask your childs doctor if they should be taking a daily dose of penicillin to prevent certain infections. There is a one in two (50%) chance that any given child will get one copy of the HbS gene and therefore have the sickle cell trait.