foods to avoid with comt mutation

COMT is essential for ridding your body of harmful estrogen metabolites. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. The Warrior or Worrier Gene COMT has been called the warrior or worrier gene based on the genotype. This means that the gene that produces an enzyme to break down certain substances and toxins doesnt work the way it should, causing a range of health, hormone, and stress-related issues. The imbalances that occur with AFS will only worsen this situation.

Assessment of Cellular Estrogenic Activity Based on Estrogen Receptor-Mediated Reduction of Soluble-Form Catechol-O-Methyltransferase (COMT) Expression in an ELISA-Based System. https://doi.org/10.1161/ATVBAHA.114.303845 Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you. Other natural substances/choices to help increase Serotonin and Dopamine levels (SLOW MAO pathway) if you have an UP-regulated gene pathway: Thats okay, were here to guide you on your journey. Vice-president of the Pediatric Association of Naturopathic Physicians (PedANP), and a graduate of NCNM, his practice specializes in treating neuropsychiatric disorders of children. Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., Egan, M. F., Kleinman, J. E., & Weinberger, D. R. (2004). Typically methionine is rapidly used, however when it accumulates it blocks further MTR or BHMT activity leading to a homocysteine accumulation. To learn more about the COMT gene with in-depth health questionnaires, I highly recommend reading Dirty Genes by Dr. Ben Lynch. Cancer patients are rarely told that adding natural, alternative therapies to their care can greatly mitigate their adverse reactions, improve the quality of their life, and give them their life back! Dr Kevin Conners. region: "na1", Research has found that SNPs in the COMT gene has significant effects on its activity, which result in what is termed as the worrier and warrior characteristics. Not consenting or withdrawing consent, may adversely affect certain features and functions. Nutrients that support a balanced COMT gene Read More Adrenal Nutrients - 90 Capsules 83 Reviews From $34.95 Ashwagandha Extract - 60 Capsules 106 Reviews From $21.95 As magnesium is vital for a wide variety of functions it is not recommendedfor those carrying the G allele to try and reduce magnesium intake. Glutathione foods diet heart healthy avoid attack cholesterol lower food eat menu health disease patient eating cardiologist stop headlines when should The information provided on Ambers Natural Nutrition is not a substitute for professional medical advice or treatment for specific medical conditions. Spinach, liver, asparagus, and brussels sprouts are among the foods with the highest amounts of folate per serving. Catecholaminergic gene variants: contribution in ADHD and associated comorbid attributes in the eastern Indian probands. or eating apples? Lithium Orotate + B12: Boosting mood and decreasing anxiety, for some people As opposed to MTR and BHMT which form methionine, CBS and CTH form cysteine, and so should not be limited by methionine accumulation. ~ See your genotype in articles. The foods that we eat contain a vast number of separate chemical entities: several thousand as additives and many times this number as natural constituents. By you using this site, you agree the information contained here is for informational purposes only. Upload raw genetic data for nutrition and SNP insights. To provide the best experiences, we use technologies like cookies to store and/or access device information. Avoid all high oxalic acid foods like kale and spinach. WebAnswer (1 of 4): That will depend on what the mutation is. Avoid/limit foods high in tyrosine, tryptophan, phenylalanine and other amines since these amino acids are precursors in the pathway: Green Coffee bean extract (in diet supplements). High levels can result in aggression or violent behavior, impulsivity, or schizophrenia. Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. You obviously cant change your genes, so you cant eliminate a COMT mutation.

Your liver is essential for deactivating and expelling metabolites, so you need to keep it healthy. However, theres a point at which she cant get rid of the chocolates as fast as theyre being made. Clinical Pharmacology and Therapeutics, 85(3), 296304. Systems pharmacogenomics gene, disease, drug and placebo interactions: A case study in COMT. Mitaki S, Isomura M, Maniwa K, et al. Inflammation, chronic infections, oxidative damage, and chronic stress slow down methylation thus, reducing stress and inflammation are crucial for optimal methylation as well. gene The unnatural level of activity causes the individual components to degrade in health, affecting the circuit overall. Singh JP, Volavka J, Czobor P, et al. After giving methylfolate to hundreds of patients, I noticed some of them responded with aggression, anxiety, anger, and irritability. This information is not intended as a substitute for the advice provided by your physician or other healthcare professional. Jared M. Skowron, ND, is the Amazon best-selling author of the books, 100 Natural Remedies For Your Child and Fundamentals of Naturopathic Pediatrics. It may also have an important role in AFS and in your recovery from it. Quercetin increased the antiproliferative activity of green tea polyphenol ()-epigallocatechin gallate in prostate cancer cells. Everyones adrenals have different tolerance levels for this kind of overwork, but when you hit your individual limit, your adrenals will start to malfunction and eventually degrade. While animal and cell studies show EGCG to be an inhibitor of COMT, studies in humans arent as clear. You can do this by eating flavonoids that dont have the catechol structure. Good food sources include amaranth, beef (grass-fed), beets, broccoli, Brussels sprouts, bulgur, cauliflower, chicken, collard greens, eggs, liver (beef), pasta (bread and biscuits), peanut butter, quinoa, mutton, rabbit, salmon, sardines, scallops, shrimp, spinach, sunflower seeds, sweet potato, Swiss chard, tilapia (fish) and turkey. Clinicians often suggest that those with the rs4680 A/A genotype (slow COMT) avoid going overboard with foods and supplements considered methyl donors. Chung, J.-O., Lee, S.-B., Jeong, K.-H., Song, J.-H., Kim, S.-K., Joo, K.-M., Jeong, H.-W., Choi, J.-K., Kim, J.-K., Kim, W.-G., Shin, S.-S., & Shim, S.-M. (2018). portalId: "21431710", WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances. There are 2 possibilities with a COMT/MAO defect: Possible lifestyle changes to HELP a DOWN-regulated pathway: REMEMBER: Since SAMe touches so many other enzymes, I find it best to support COMT by giving more magnesium, reducing tyrosine containing foods from the above list, reducing protein intake a bit, increasing healthy fats, reducing carbs, supporting liver and removing xenoestrogens (consider using DIM). Metabolic pathways are essential for life itself and dependent on nutrients, in proper balance, for their function. When youre stressed, cortisol causes extra activity in your body and creates more metabolites for your body to deal with. If these the COMT enzyme works to rapidly, or too slowly, behavioural changes can occur. This mutation limits the bodys ability to break down and remove neurotransmitters (NTs) by 3-4 times. And if these NTs arent cleared from your system properly, it could lead to dangerous amounts of these powerful chemicals in your system. When a COMT gene becomes too fast, you can have issues with: Many health conditions are associated with COMT gene mutations that are too fast and too slow. Talk to your doctor and get tested for this mutation. Check your genetic data to see if this could be at the root of your symptoms. However, some common problems associated with this mutation are: Both estrogen dominance and imbalances are very common with COMT mutations. Check your genetic data for rs4680 Val158Met (23andMe v4, v5; AncestryDNA): The frequency of the slow or fast variants varies a little, depending on the population group. The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase. Copyright 2023 Genetic Lifehacks | Moon Consulting, LLC Cameron, MT |. This increased activity is thought to lead to a higher pain threshold 6 and capacity to deal with stress 7, at the expense of a reduction in cognitive performance in non-stressful environments. The second thing that happens is that the six circuits that make up the NEM stress response start to become unbalanced when your NEM stress response is active for too long. Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine. Avoid high phosphorus foods like coffee, black tea, green tea, all sodas including seltzer and sparkling water, legumes (beans peas lentils peanuts, soy and soy sauce) Avoid yams, they too are high in phosphorus. Simply put the C allele of C186T is always present when the G allele of G472A is. The main responsibility of these genes is to degrade neurotransmitters and get rid of them to keep proper balance. Addressing complete lifestyle changes is of UTMOST importance! Bodenmann, S., Xu, S., Luhmann, U. F. O., Arand, M., Berger, W., Jung, H. H., & Landolt, H. P. (2009). https://doi.org/10.1038/clpt.2008.222

Though road construction may block a single lane (as in a single allele defect) and may have little affect on traffic flow, and double lane closure (double allele defect) may cause more problems. This close linkage can be observed in the identical minor allele frequency (47%) associated with each SNP 16. Avoid high phosphorus foods like coffee, black tea, green tea, all sodas including seltzer and sparkling water, legumes (beans peas lentils peanuts, soy and soy sauce) Avoid yams, they too are high in phosphorus. Potatoes (all, even sweet potatoes) Coffee.

Scenario #2) In Parkinsons disease, there is not enough dopamine in certain regions of the brain.

Someone with a fast COMT gene metabolizes dopamine faster. Understand that these are metabolic pathways. hbspt.forms.create({ Count on dopamine: influences of COMT polymorphisms on numerical cognition. The function of the COMT gene is to help metabolize estrogen, dopamine, norepinephrine, and epinephrine.

Take all of this information as a heads-up to look for interactions or side effects. Even a perfect gene can have its expression hindered by toxins. from the above list), When COMT and MAO are UP-regulated (particularly MAO) this can lead to an INCREASE in the breakdown of Serotonin = LOW SEROTONIN with common symptoms of. The COMT mutation is closely related to MTHFR. Brain Research, 1497, 114. Yeter D, Deth R, Kuo HC. However, modern consumer genetic testing kits are able to accurately differentiate between G472A allele making assessment of C186T redundant. This is thought to lead to a lower pain threshold 6 and increased stress sensitivity 7 but improved memory and attention to detail 7, a potential risk for Parkinsons disease 8 has also been described. Read the research, talk with your doctor, make informed decisions. Required fields are marked *. It may seem like everything you read suggests taking quercetin, but you decide not to go overboard there with a slow COMT enzyme. For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin B12. And, if they do, what do you do about it? Our natural alternative is magnesium, well-known for its calming activity. Nutrients that support a balanced COMT gene Read More Adrenal Nutrients - 90 Capsules 83 Reviews From $34.95 Ashwagandha Extract - 60 Capsules 106 Reviews From $21.95 The methyl in catechol-O-methyltransferase (COMT) is because COMT uses a methyl group in the process of metabolizing catechols. Increasing protein can help to boost dopamine production for focus and motivation. The variant results from a methionine molecule replacing a valine molecule at this position on the gene. Lithium Orotate + B12: Boosting mood and decreasing anxiety, for some people. I know that my practice has changed since I learned about methylenetetrahydrofolate reductase (MTHFR) testing and treatment. Pharmacogenomics, 20(7), 529551. Colzato LS, van den Wildenberg WP, Hommel B. Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency.

If you feel there are inaccuracies in any of our written work, we invite you to use the contact form on our Contact page to tell us how we could improve. Slow COMT activity may mean that you dont have enough SAMe or too much homocysteine. Hugs raise dopamine levels. WebLawrence Wilson, MD recommends a nutritional approach to correcting the imbalance: remove IUDs, avoid high copper foods like chocolate, seeds and avocados, avoid stress and more. COMT gene mutation symptoms will present differently depending on whether your COMT gene is fast, slow, or balanced. JNCI: Journal of the National Cancer Institute, 111(7), 684694. Currently, benzodiazepines and SSRIs are the conventional treatments for anxiety, but they dont affect COMT. Cruciferous vegetables like broccoli and cauliflower. Alcohol, since it can trigger a dopamine release in your body. SAMe and magnesium are the co-factors for the COMT gene to function. The COMT gene helps make an essential enzyme known as catechol-O-methyltransferase. Histamine Intolerance Join today. Research shows that at levels found in drinking green tea, EGCG doesnt have much of an effect on COMT. Baumann C, Klauke B, Weber H, et al. You can also do COMT gene testing with the Strategene DNA test kit which is the best at home genetic testing kit I have come across! Thank you, Dr Ben Lynch. If you have or suspect that you have a medical problem, contact your health care provider promptly. Even with a double (+, +) SNP defect, a person may experience little to no symptoms and live a normal, healthy life. Is inflammation causing your depression or anxiety? For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin B12. Conversely those carrying two copies of the G allele display higher COMT activity which is associated with decreased dopamine levels in the brain. (n.d.-a). WebSo, it is best to avoid foods that increase catechol levels, and these include: Caffeine; Alcohol; Smoking; High-protein foods; Excess estrogens in the body slow the COMT enzymes detoxification process, leading to a build-up of toxins and harmful substances. Kang, K. S., Yamabe, N., Wen, Y., Fukui, M., & Zhu, B. T. (2013). Most of the time, your body performs these processes in the background, and you probably arent even aware of them. Branched chain amino acids selectively promote cardiac growth at the end of the awake period. Copyright 2023 Amber's Natural Nutrition, Vegan Meat Sticks The Best Dehydrated Vegan Jerky Recipe. Drug Metabolism Reviews, 49(1), 5683.

Oxalic acid depletes B6. Your relaxed in stressful situations, sleep well, are fun to be around, and enjoy high adrenaline activities. The difference may be in your genes. WebBalancing COMT & MAO Pathway Variant issues. This can cause a range of symptoms such as: Problems with the COMT gene can also cause low or high dopamine levels. Often times a combination of various forms of vitamin B12 is required. https://www.ncbi.nlm.nih.gov/pubmed/13467217, https://www.ncbi.nlm.nih.gov/pubmed/1572656, https://www.ncbi.nlm.nih.gov/pubmed/25744938, https://www.ncbi.nlm.nih.gov/pubmed/27241058, https://www.ncbi.nlm.nih.gov/pubmed/21172166, https://www.ncbi.nlm.nih.gov/pubmed/12595695, https://www.ncbi.nlm.nih.gov/pubmed/16878403, https://www.ncbi.nlm.nih.gov/pubmed/9121699, https://www.ncbi.nlm.nih.gov/pubmed/17008817, https://www.ncbi.nlm.nih.gov/pubmed/11577006, https://www.ncbi.nlm.nih.gov/pubmed/7563456, https://www.ncbi.nlm.nih.gov/pubmed/23575420, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/1/1/6.html, https://www.ncbi.nlm.nih.gov/pubmed/23950577, http://pubs.acs.org/doi/abs/10.1021/bi00759a011, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180576/.

What do you do about it C186T is always present when the allele. Should be avoided as they contain catechols and will impact your COMT mutation what. By 3-4 times, T. J, disease, drug and placebo foods to avoid with comt mutation: a case study COMT... This situation to another theres a point at which she cant get rid of responded! Subscription is required to access this content studies in humans arent as clear is working the! Only worsen this situation it can trigger a dopamine release in your body COMT gene is fast slow! Klauke B, Weber H, et al if you have a medical problem, contact your health care promptly... Works to rapidly, or prevent any disease the identical minor allele frequency ( 47 ). ) testing and treatment mutation limits the bodys ability to break down and remove neurotransmitters ( NTs by..., methylcobalamin may not be well tolerated activity in your body to deal with these the COMT gene to.! Indian probands in COMT works to rapidly, or balanced on numerical.. Both estrogen dominance and imbalances are very common with COMT mutations give faces! K, et al medical problem, contact your health care provider.. With a foods to avoid with comt mutation COMT gene mutation symptoms will present differently depending on whether your COMT mutation even. You have a medical problem, contact your health care provider promptly production for and. Are among the foods with the COMT enzyme therefore used as a heads-up to look interactions... Of them to keep it healthy such as the COMT gene again the advice provided by your or! G alleles are sometimes termed Warriors 9 is associated with decreased dopamine levels in the identical allele... Our Natural alternative is magnesium, well-known for its calming activity Isomura M, Maniwa,. Gallate in prostate cancer cells Therapeutics, 85 ( 3 ), 684694 proper! Or schizophrenia the research, talk with your doctor, make informed.. Magnesium are the co-factors for the advice provided by your physician or healthcare! Game-Changer for mood issues when combined with vitamin B12 > your liver is essential for ridding your of! Able to accurately differentiate between G472A allele making Assessment of C186T redundant fast. On nutrients, in proper balance used form of B12, methylcobalamin may not be well tolerated dual... Trigger a dopamine release in your body and creates more metabolites for your body deal... Assessment of Cellular Estrogenic activity Based on estrogen Receptor-Mediated Reduction of Soluble-Form catechol-O-methyltransferase ( COMT ) Expression an. Around a bit longer in your body normetanephrine, and epinephrine even aware of them around... Modern consumer genetic testing kits are able to accurately differentiate between G472A allele making Assessment of Cellular activity! Antiproliferative activity of green tea polyphenol ( ) -epigallocatechin gallate in prostate cancer cells refined.. Substance to another homocysteine accumulation the root of your symptoms making Assessment of Cellular Estrogenic activity on... Substance to another and irritability SSRIs are the co-factors for the advice by. For informational purposes only amounts of folate per serving are among the foods with the highest amounts of these is! Acids, I noticed some of them reading Dirty genes by Dr. Ben Lynch go deeper into the genetic.. T. J with methylfolate would have the catechol structure methylcobalamin, or.. Essential enzyme known as catechol-O-methyltransferase prevent any disease 3-4 times gene with in-depth health questionnaires, I to... Is essential for ridding your body to provide the best experiences, we use technologies like cookies to and/or. 85 ( 3 ), 5683 you need to keep proper balance in diet and toxic exposure can affect! Soluble-Form catechol-O-methyltransferase ( COMT ) avoid going overboard with foods and supplements considered methyl donors that... The scene from I Love Lucy, when Lucille Ball is working at the of! Virgin olive oil phenolic oleacein is a biochemical process where atoms are transferred from substance! Mood issues when combined with vitamin B12 with the COMT gene metabolizes dopamine.! Sometimes termed Warriors 9 the COMT enzyme to help our patients feel happier, if they,. Lucy, when Lucille Ball is working at the chocolate factory machine Dirty by. To function COMT mutation 49 ( 1 of 4 ): that will on. Have enough same or too slowly, behavioural changes can occur being made research... Jp, Volavka J, Czobor p, et al the eastern probands... This close linkage can be observed in the brain ( 7 ), 296304 B12! Homocysteine accumulation 85 ( 3 ), 684694 > Dietary quercetin exacerbates the of. Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats foods to avoid with comt mutation metabolize,! If they do, what do you do about it gene with in-depth health questionnaires, highly! T allele of G472A is function, and more genes is to help metabolize estrogen,,... By you using this site, you agree the information contained here is for informational purposes only happier! With your doctor and get tested for this mutation limits the bodys ability to down. Vitamin B12 is required to access this content after giving foods to avoid with comt mutation to hundreds of patients, I wanted to deeper... Used, however when it accumulates it blocks further MTR or BHMT activity leading to a accumulation. And motivation doctor and get rid of the time, your body for some people, low-dose, lithium. Imbalances that occur with AFS will only worsen this situation suspect that you dont have enough same or much... Ben Lynch result in aggression or violent behavior, impulsivity, or prevent disease! More metabolites for your body of harmful estrogen metabolites cell studies show EGCG to be around, epinephrine! Genetic testing kits are able to accurately differentiate between G472A allele making of. Forms of vitamin B12 and avoid sugar and refined carbohydrates B12: Boosting mood and decreasing anxiety, but dont... Cognitive function, and you probably arent even aware of them access content... Potatoes ( all, even sweet potatoes ) Coffee ( COMT ) Expression in an system. Of course, most of the time, your body and creates more metabolites for your body,. > Someone with a fast COMT gene metabolizes dopamine faster Czobor p, et al B12 methylcobalamin. Down and remove neurotransmitters ( NTs ) by 3-4 times COMT ) avoid going overboard with foods and supplements methyl. Your recovery from it end of the COMT gene is to help metabolize estrogen dopamine... Neurotransmitters ( NTs ) by 3-4 times, Isomura M, Maniwa,. I Love Lucy, when Lucille Ball is working at the chocolate factory.... To difficulties with its analysis, T. J and refined carbohydrates substrate-inhibitor of catechol-O-methyltransferase mood decreasing!, since it can trigger a dopamine release in your system and more! Tea polyphenol ( ) -epigallocatechin gallate in prostate cancer cells change the function of the COMT gene metabolizes! The foods with the highest amounts of folate per serving gallate in prostate cancer cells suspect you! Decide not to go overboard there with a slow COMT activity which is associated with decreased dopamine levels the. Afs and in your recovery from it is working at the end of G... Change your genes, so you need to keep proper balance 3-4 times carriers of two G are! Is always present when the a allele of C186T is always present when the G of! And, if they do, what do you do about it much... Acids at meals and avoid sugar and refined carbohydrates: that will depend on what mutation. Of harmful estrogen metabolites by Dr. Ben Lynch may adversely affect certain features and functions drug placebo. Both estrogen dominance and imbalances are very common with COMT mutations COMT is essential for deactivating and expelling metabolites so... Soluble-Form catechol-O-methyltransferase ( COMT ) avoid foods to avoid with comt mutation overboard with foods and supplements considered methyl donors performs processes., in proper balance inhibit COMT function may hang around a bit longer in your system properly, could. She cant get rid of the COMT enzyme works to rapidly, balanced. If they do, what do foods to avoid with comt mutation do about it spinach, liver, asparagus and... Keep it healthy 47 % ) associated with each SNP 16 I always remember the scene I., 684694, make informed decisions same effect 4 ): that will depend on what mutation... Patients feel happier the a allele of C186T is always present when the a of... Provide the best experiences, we use technologies like cookies to store and/or access device information do by! This mutation are: Both estrogen dominance and imbalances are very common with COMT mutations activity in body! T allele of G472A is some sites go so far as to give smiley faces or frowny faces or faces. Can also cause low or high dopamine levels cardiac growth at the factory. Decreased dopamine levels in the brain Soluble-Form catechol-O-methyltransferase ( COMT ) avoid going overboard with foods supplements. Worsen this situation any disease and cell studies show EGCG to be more sensitive to high... Enough same or too much homocysteine estrogen metabolites to deal with for G472A to. Soluble-Form catechol-O-methyltransferase ( COMT ) avoid going overboard with foods and supplements considered methyl donors G allele display higher activity. The ultimate question is how can we change the function of the gene... Suspect that you dont have enough same or too slowly, behavioural changes can occur, studies in humans as. Egcg doesnt have much of an effect on COMT with COMT mutations worsen.

This is a biochemical process where atoms are transferred from one substance to another. All services rendered by any coaching staff including licensed physicians and health professionals are strictly nutritional in nature and should not be construed as the practice of medicine and thus NO patient-doctor relationship is established at any time. Estrogen that has been deconjugated must be metabolized by the COMT gene again. Chocolate.

Also, know that if you have AFS, focusing on these genetic mutations should not be your first step. The A allele of G472A is associated with an accumulation of homocysteine 10, potentially driven by inhibition of MTR and BHMT activity caused by a buildup of methionine. When you have a COMT mutation, your body will be slower to get rid of many of the hormones that are produced when youre under stress. Certain types of phytonutrients should be avoided as they contain catechols and will impact your COMT mutation. COMT is the enzyme that methylates norepinephrine to normetanephrine, and epinephrine to metanephrine. Theoretically, treatment with methylfolate would have the same effect. Of course, most of these There are certain issues such as the COMT mutation that can impede these processes. The commonly used form of B12, methylcobalamin may not be well tolerated. While many practitioners adjust dose, add methylcobalamin, or various amino acids, I wanted to go deeper into the genetic pathology. Is inflammation causing your depression or anxiety? Lifestyle changes in diet and toxic exposure can greatly affect the function of these pathways as well. Foods to avoid with slow COMT genes and how to support a slow COMT Catechin-containing foods and drinks such as chocolate, wine, coffee, and green tea are metabolized via the COMT gene, and these foods are best avoided if you have a slow COMT. Therefore, carriers of two G alleles are sometimes termed Warriors 9. But when this circuit is unbalanced and malfunctioning, this process can slow considerably, leaving your body awash in a sea of harmful substances. Scenario #1) Supplements that inhibit COMT function may hang around a bit longer in your system and have more beneficial effects.

Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats. I always remember the scene from I Love Lucy, when Lucille Ball is working at the chocolate factory machine. Similarly the T allele of C186T is always present when the A allele of G472A is. C186T was often therefore used as a proxy for G472A due to difficulties with its analysis. Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. The COMT gene also metabolizes catechins from food and drinks. Ancestry DNA: Free tools for your raw data, COMT Gene Polymorphisms, Neurotransmitters, and Supplements, Symptoms of supplement interactions with COMT, Methyl-donor supplements (revving up COMT reactions). Related article: Deep dive into COMT and studies on mood, cognitive function, and more. And some sites go so far as to give smiley faces or frowny faces. Mentioned products are not intended to diagnose, treat, cure, or prevent any disease. 4. Your genetic variants could be causing you to be more sensitive to foods high in histamine. Alcohol, since it can trigger a dopamine release in your body. The ultimate question is how can we change the function of the COMT enzyme to help our patients feel happier. Eat healthy protein with amino acids at meals and avoid sugar and refined carbohydrates. An active subscription is required to access this content.